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ea0037gp.04.05 | Steroids | ECE2015

Glucocorticoid receptor and HSD11B1 gene polymorphisms influence the therapy and therapy-associated morbidities in patients with Addison's disease

Molnar Agnes , Kovesdi Annamaria , Szucs Nikolette , Toth Miklos , Igaz Peter , Racz Karoly , Patocs Attila

Objective: Glucocorticoids exert their effects through the glucocorticoid receptor (GR). The local, cell-type specific glucocorticoid effect is modulated by the 11β-hydroxysteroid dehydrogenase enzymes (HSD11B) responsible for the interconversion of cortisone and cortisol. Individual sensitivity against glucocorticoids and activity of the HSD11B enzymes are at least partly determined by genetic factors.Aim: To test whether SNPs of GR and HSD11B1 gen...

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ea0063p861 | Adrenal and Neuroendocrine Tumours 3 | ECE2019

Neuroendocrine neoplasms: experiences of a single tertiary referral endocrine centre in Hungary

Tőke Judit , Pocsai Karoly , Major Judit , Kollar Reka , Szatmari Reka , Stark Julia , Molnar Agnes , Szucs Nikolette , Reismann Peter , Nagy Geza , Pusztai Peter , Sarman Beatrix , Lohinszky Julia , Uhlyarik Andrea , Borka Katalin , Sapi Zoltan , Huszty Gergely , Varga Zsolt , Dabasi Gabriella , Igaz Peter , Toth Miklos

Introduction: Clinicopathological characterisation ofneuroendocrine neoplasms could provide improved prognostic information even at the time of the diagnosis.Objectives: The aim of this study was to characterise the clinicopathological features of a large cohort of patients with neuroendocrine neoplasms (NENs).Patients and methods: The study included 210 patients (95 men and 115 women) with histologically confirmed and verified neu...

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Endocrine Abstracts

Glucocorticoid receptor and HSD11B1 gene polymorphisms influence the therapy and therapy-associated morbidities in patients with Addison's disease

Neuroendocrine neoplasms: experiences of a single tertiary referral endocrine centre in Hungary

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